Located within 10 minutes' drive of Castel Sant'Elmo, Casa Donnaregina Hotel Naples is only a 6-minute stroll from Orto Botanico di Napoli.

The historic Botanical Garden of Naples is a mere 500 metres away, while Piazza Cavour train station is within walking distance of the bed & breakfast. Religious sights in the area include San Giovanni a Carbonara Gothic Church (0.8 km) and Catacombs of San Gaudioso (1.2 km). Piazza del Plebiscito is a 10-minute drive from this Naples hotel. There is Tenore bus stop a mere 5 minutes' walk away.

Welcoming guests to a balcony and a dressing room, the rooms are furnished with a sofa set. A bidet, a walk-in shower, and a separate toilet, along with hairdryers and towels, are provided.

The property is within a short walking distance of the seafood restaurant Bellavista SAS Di Pacifico Assunta.